ST8SIA2

Across TCGA patient cohorts, ST8SIA2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST8SIA2-associated genes across cancer lineages are S6_pS240_S244, p62 Lck ligand, and ATM. Each is linked with ST8SIA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST8SIA2-to-partner and partner-to-ST8SIA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by ST8SIA2-low versus ST8SIA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA2→partner) and Y-score (partner→ST8SIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.294	+2.222	.036	.010	3	3
UCEC	p62 Lck ligand →	+0.251	+1.916	.026	.009	3	2
UCEC	ATM →	-0.540	-2.070	<.001	.001	3	2
UCEC	Di-Ras3 →	-0.217	-3.584	<.001	<.001	3	2
COAD	ASNS →	+0.836	+2.815	<.001	.036	3	1
SKCM	EGFR →	-0.171	-2.321	.012	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

S6_pS240_S244 by ST8SIA2 expression — UCEC

Explore this box plot interactively →