ST8SIA2

Across TCGA pan-cancer cohorts, ST8SIA2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ST8SIA2 data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ST8SIA2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ST8SIA2 expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.

UVM, SKCM, and UCS are the cancer types where ST8SIA2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.370	0.881	<.001	158	view →
SKCM	OS	Quartile	All	0.276	0.446	<.001	80	view →
UCS	DFS	Median	II,III,IV	0.576	0.138	<.001	70	view →
LGG	DFS	Median	All	0.480	0.301	<.001	53	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	36	view →
ACC	DFS	Tertile	All	0.282	0.801	<.001	30	view →
BRCA	OS	Median	III,IV	0.658	0.411	.002	26	view →
KIRC	DFS	Quartile	All	0.568	0.732	.004	16	view →
COAD	OS	Tertile	IV	0.893	0.252	.005	12	view →
STAD	OS	Tertile	IV	0.546	0.200	.018	12	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	12	view →
LUSC	DFS	Median	III,IV	0.267	0.493	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ST8SIA2–UVM (OS)

Open the UVM breakdown →