ST8SIA2

Across TCGA pan-cancer cohorts, ST8SIA2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of ST8SIA2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ST8SIA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ST8SIA2 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, KICH, and LUAD are the cancer types where ST8SIA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST8SIA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.816	<.001	11	view →
KICH	All	All	−0.363	<.001	10	view →
LUAD	All	II,III,IV	+0.490	<.001	8	view →
UCEC	All	All	+1.296	<.001	6	view →
BRCA	Female	All	−0.929	<.001	6	view →
LUSC	All	All	+0.777	<.001	6	view →
THCA	All	All	+0.401	<.001	6	view →
COAD	Female	III,IV	−0.138	.006	1	view →
READ	All	All	−0.118	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

ST8SIA2–HNSC

Open the HNSC breakdown →