ST8SIA2

Across TCGA cell cohorts, ST8SIA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,977 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ST8SIA2-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Regulation of G1/S transition of mitotic cell cycle, and Protein localization to nucleus. Each is linked with ST8SIA2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ST8SIA2-to-partner and partner-to-ST8SIA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by ST8SIA2-low versus ST8SIA2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA2→partner) and Y-score (partner→ST8SIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of cell cycle process →	+0.055	+1.972	<.001	<.001	3	7
LUNG_SCLC	Regulation of G1/S transition of mitotic cell cycle →	+0.074	+1.854	<.001	.005	3	7
LUNG_SCLC	Protein localization to nucleus →	+0.050	+1.789	<.001	<.001	3	7
LUNG_SCLC	Protein-DNA complex organization →	+0.061	+1.611	<.001	<.001	3	7
LUNG_NSCLC_LUSC	Transcription initiation at RNA polymerase II promoter →	+0.048	+0.910	<.001	.006	3	6
LUNG_SCLC	Negative regulation of endopeptidase activity →	-0.977	-1.553	.008	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,977 associations by consensus.

Negative regulation of cell cycle process by ST8SIA2 expression — LUNG_SCLC

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