ST8SIA1

Across TCGA patient cohorts, ST8SIA1 mutation is significantly associated with the RNA expression of many other genes, with 2,451 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST8SIA1-associated genes across cancer lineages are RPS3AP9, SLC6A14P3, and NRG1-IT1. Each is linked with ST8SIA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST8SIA1-to-partner and partner-to-ST8SIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS3AP9 grouped by ST8SIA1-low versus ST8SIA1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA1→partner) and Y-score (partner→ST8SIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPS3AP9 →	+0.090	+3.024	<.001	.009	3	2
COAD	SLC6A14P3 →	+0.159	+4.332	<.001	.006	3	2
LUAD	NRG1-IT1 →	+0.419	+3.073	<.001	.008	3	2
UCEC	CETN3 →	+0.643	+3.010	<.001	<.001	3	2
UCEC	SLC45A1 →	-0.528	-3.000	.001	.001	3	2
UCEC	SNED1 →	-0.613	-2.321	.005	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,451 associations by consensus.

RPS3AP9 by ST8SIA1 expression — LUAD

Explore this box plot interactively →