ST8SIA1

Across TCGA pan-cancer cohorts, ST8SIA1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ST8SIA1 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ST8SIA1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ST8SIA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

UVM, HNSC, and KIRP are the cancer types where ST8SIA1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.299	0.715	<.001	108	view →
HNSC	DFS	Tertile	All	0.450	0.233	<.001	90	view →
KIRP	OS	Quartile	All	0.511	0.802	.003	83	view →
ACC	OS	Median	All	0.427	0.925	<.001	45	view →
ESCA	DFS	Tertile	III,IV	0.566	0.203	<.001	40	view →
LUAD	DFS	Median	All	0.726	0.607	<.001	39	view →
LGG	DFS	Median	All	0.802	0.669	<.001	28	view →
COAD	DFS	Quartile	IV	0.167	0.533	.005	15	view →
KICH	DFS	Median	All	0.655	1.000	.011	13	view →
LUSC	DFS	Quartile	All	0.881	0.590	.002	12	view →
THYM	DFS	Median	III,IV	1.000	0.441	.004	10	view →
PAAD	DFS	Quartile	All	0.562	0.296	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ST8SIA1–UVM (DFS)

Open the UVM breakdown →