ST8SIA1

Across TCGA pan-cancer cohorts, ST8SIA1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ST8SIA1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ST8SIA1 RNA is repressed in tumor relative to normal tissue. In most cancer types ST8SIA1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and UCEC are the cancer types where ST8SIA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST8SIA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−1.241	<.001	11	view →
COAD	Male	II,III,IV	−0.560	<.001	10	view →
UCEC	All	III,IV	−1.326	<.001	8	view →
BRCA	All	III,IV	−0.958	<.001	8	view →
HNSC	All	III,IV	+0.471	.001	7	view →
LUAD	Female	III,IV	−0.625	<.001	6	view →
THCA	Female	II,III,IV	−0.523	<.001	6	view →
CHOL	All	All	+0.333	.004	4	view →
KIRC	Male	All	+0.244	.002	4	view →
READ	Female	All	−1.224	.004	2	view →
PRAD	All	All	−0.637	<.001	2	view →
KICH	Female	All	−0.387	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ST8SIA1–BLCA

Open the BLCA breakdown →