ST8SIA1

Across TCGA patient cohorts, ST8SIA1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST8SIA1-associated genes across cancer lineages are FoxM1, JNK2, and Ku80. Each is linked with ST8SIA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST8SIA1-to-partner and partner-to-ST8SIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by ST8SIA1-low versus ST8SIA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA1→partner) and Y-score (partner→ST8SIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.331	+2.807	.003	.003	3	2
UCEC	JNK2 →	+0.267	+2.115	.002	.019	3	2
UCEC	Ku80 →	+0.265	+1.598	.010	.044	3	2
UCEC	Rab25 →	-0.401	-3.321	.005	.010	3	2
UCEC	Annexin-1 →	+0.594	+3.019	.009	.019	3	2
UCEC	Stathmin →	+0.155	+2.807	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FoxM1 by ST8SIA1 expression — UCEC

Explore this box plot interactively →