ST8SIA1

Across TCGA cell cohorts, ST8SIA1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ST8SIA1-associated genes across cancer lineages are HMGXB4, SH3GL2, and SERAC1. Each is linked with ST8SIA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST8SIA1-to-partner and partner-to-ST8SIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGXB4 grouped by ST8SIA1-low versus ST8SIA1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST8SIA1→partner) and Y-score (partner→ST8SIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HMGXB4 →	+0.601	+3.067	.005	.009	3	1
LARGE_INTESTINE	SH3GL2 →	+1.502	+3.474	<.001	.003	3	1
LARGE_INTESTINE	SERAC1 →	+0.829	+3.067	<.001	.009	3	1
LARGE_INTESTINE	ZCCHC2 →	+1.155	+3.067	<.001	.009	3	1
LARGE_INTESTINE	SKA1 →	+0.825	+3.067	.007	.009	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.023	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

HMGXB4 by ST8SIA1 expression — LARGE_INTESTINE

Explore this box plot interactively →