ST6GALNAC6

Across TCGA cell cohorts, ST6GALNAC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,785 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ST6GALNAC6-associated GO terms across cancer lineages are Negative regulation of smoothened signaling pathway, Ganglioside metabolic process, and Response to oscillatory fluid shear stress. Each is linked with ST6GALNAC6 in more than 12 cancer types. Because this analysis shows association rather than direction, both ST6GALNAC6-to-partner and partner-to-ST6GALNAC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of smoothened signaling pathway grouped by ST6GALNAC6-low versus ST6GALNAC6-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GALNAC6→partner) and Y-score (partner→ST6GALNAC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of smoothened signaling pathway →	+0.058	+0.942	<.001	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Ganglioside metabolic process →	+0.114	+0.981	<.001	<.001	3	12
STOMACH	Response to oscillatory fluid shear stress →	+0.214	+1.436	<.001	.001	2	13
STOMACH	Cellular response to oscillatory fluid shear stress →	+0.214	+1.436	<.001	.001	2	13
STOMACH	Vascular endothelial cell response to oscillatory fluid shear stress →	+0.214	+1.436	<.001	.001	2	13
LIVER	Glycosylceramide metabolic process →	+0.259	+1.207	<.001	.003	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,785 associations by consensus.

Negative regulation of smoothened signaling pathway by ST6GALNAC6 expression — URINARY_TRACT

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