ST6GALNAC6

Across TCGA pan-cancer cohorts, ST6GALNAC6 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ST6GALNAC6 data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ST6GALNAC6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ST6GALNAC6 expression acts as an unfavorable survival marker, although some lineages such as LUAD and KIRC show a favorable association.

ACC, LUAD, and LUSC are the cancer types where ST6GALNAC6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.212	0.699	<.001	90	view →
LUAD	OS	Median	II,III,IV	0.670	0.463	<.001	70	view →
LUSC	OS	Quartile	All	0.281	0.521	<.001	52	view →
KIRC	DFS	Median	All	0.707	0.546	.001	41	view →
OV	OS	Quartile	All	0.274	0.425	.002	34	view →
LAML	DFS	Quartile	All	0.266	0.732	<.001	32	view →
SKCM	OS	Quartile	II,III,IV	0.443	0.244	.001	23	view →
PAAD	DFS	Median	All	0.365	0.229	.011	21	view →
THCA	OS	Median	II,III,IV	0.958	0.335	.019	19	view →
UCS	OS	Tertile	IV	0.176	0.783	.024	14	view →
ESCA	OS	Tertile	All	0.726	0.422	.007	13	view →
PRAD	DFS	Tertile	All	0.836	0.936	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ST6GALNAC6–ACC (DFS)

Open the ACC breakdown →