ST6GALNAC6

Across TCGA pan-cancer cohorts, ST6GALNAC6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ST6GALNAC6’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ST6GALNAC6 RNA is repressed in tumor relative to normal tissue. In most cancer types ST6GALNAC6 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LUAD are the cancer types where ST6GALNAC6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST6GALNAC6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−2.517	<.001	11	view →
COAD	All	III,IV	−2.389	<.001	11	view →
LUAD	Female	III,IV	−1.725	<.001	11	view →
LUSC	Female	II,III,IV	−1.841	<.001	9	view →
KIRP	Female	All	−1.137	<.001	9	view →
KICH	Female	All	−1.265	<.001	8	view →
BRCA	All	II,III,IV	−1.111	<.001	8	view →
KIRC	Male	II,III,IV	−0.477	<.001	7	view →
UCEC	All	All	−2.264	<.001	6	view →
READ	Female	All	−3.118	<.001	5	view →
THCA	Male	All	+0.396	<.001	4	view →
PAAD	All	All	−0.564	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ST6GALNAC6–BLCA

Open the BLCA breakdown →