ST6GALNAC4

Across TCGA patient cohorts, ST6GALNAC4 mutation is significantly associated with the RNA expression of many other genes, with 1,118 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST6GALNAC4-associated genes across cancer lineages are RNU7-77P, RN7SL592P, and DOT1L. Each is linked with ST6GALNAC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST6GALNAC4-to-partner and partner-to-ST6GALNAC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-77P grouped by ST6GALNAC4-low versus ST6GALNAC4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST6GALNAC4→partner) and Y-score (partner→ST6GALNAC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU7-77P →	+0.380	+2.683	.003	.005	3	2
UCEC	RN7SL592P →	+0.137	+2.023	.008	.006	3	2
UCEC	DOT1L →	+0.615	+3.716	<.001	<.001	3	2
UCEC	STIM2 →	+0.551	+2.243	<.001	.006	3	2
UCEC	USP12 →	+0.547	+3.640	.002	.001	3	2
UCEC	EXOSC10 →	+0.421	+2.949	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,118 associations by consensus.

RNU7-77P by ST6GALNAC4 expression — SKCM

Explore this box plot interactively →