ST3GAL5

Across TCGA cell cohorts, ST3GAL5 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ST3GAL5-associated genes across cancer lineages are MFSD14A, LDLRAP1, and ADAMTS4. Each is linked with ST3GAL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST3GAL5-to-partner and partner-to-ST3GAL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MFSD14A grouped by ST3GAL5-low versus ST3GAL5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST3GAL5→partner) and Y-score (partner→ST3GAL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MFSD14A →	+0.698	+3.064	<.001	.009	3	1
LARGE_INTESTINE	LDLRAP1 →	+0.686	+3.064	.002	.009	3	1
LARGE_INTESTINE	ADAMTS4 →	+0.102	+3.112	.001	.001	3	1
LARGE_INTESTINE	EN1 →	+1.143	+3.536	<.001	.003	3	1
LARGE_INTESTINE	ACER1 →	+0.062	+3.408	.009	<.001	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+2.977	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

MFSD14A by ST3GAL5 expression — LARGE_INTESTINE

Explore this box plot interactively →