ST3GAL5

Across TCGA pan-cancer cohorts, ST3GAL5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ST3GAL5 data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher ST3GAL5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ST3GAL5 expression acts as an unfavorable survival marker, although some lineages such as BLCA and CESC show a favorable association.

BLCA, KIRP, and CESC are the cancer types where ST3GAL5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	0.787	0.653	<.001	85	view →
KIRP	DFS	Median	All	0.861	0.954	.001	75	view →
CESC	DFS	Tertile	II,III,IV	0.868	0.619	.003	62	view →
KIRC	DFS	Median	II,III,IV	0.633	0.783	.001	58	view →
ESCA	DFS	Median	II,III,IV	0.506	0.275	<.001	54	view →
THCA	OS	Median	II,III,IV	1.000	0.324	.001	51	view →
ACC	DFS	Median	All	0.386	0.765	<.001	49	view →
UVM	DFS	Tertile	All	0.345	0.763	.007	48	view →
LUSC	DFS	Quartile	II,III,IV	0.599	0.820	<.001	47	view →
SARC	DFS	Quartile	All	0.642	0.394	<.001	22	view →
HNSC	OS	Tertile	III,IV	0.510	0.763	.005	21	view →
LUAD	OS	Quartile	All	0.873	0.737	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ST3GAL5–BLCA (OS)

Open the BLCA breakdown →