ST20-MTHFS

Across TCGA patient cohorts, ST20-MTHFS mutation is significantly associated with the RNA expression of many other genes, with 499 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST20-MTHFS-associated genes across cancer lineages are NDUFAF2P1, MIR1291, and BRI3BP. Each is linked with ST20-MTHFS in more than 1 cancer types. Because this analysis shows association rather than direction, both ST20-MTHFS-to-partner and partner-to-ST20-MTHFS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NDUFAF2P1 grouped by ST20-MTHFS-low versus ST20-MTHFS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST20-MTHFS→partner) and Y-score (partner→ST20-MTHFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NDUFAF2P1 →	+0.752	+3.332	.001	.005	3	1
UCEC	MIR1291 →	+0.628	+2.757	.003	.008	3	1
UCEC	BRI3BP →	+0.766	+3.332	.003	.005	3	1
UCEC	EOLA1 →	+0.521	+3.364	.008	.005	3	1
UCEC	RNU6-668P →	+0.409	+3.356	<.001	.005	3	1
UCEC	RNU6-4P →	+0.606	+3.234	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 499 associations by consensus.

NDUFAF2P1 by ST20-MTHFS expression — UCEC

Explore this box plot interactively →