ST20-MTHFS

Across TCGA pan-cancer cohorts, ST20-MTHFS RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ST20-MTHFS data layer compared with 1 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher ST20-MTHFS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ST20-MTHFS expression acts as an unfavorable survival marker, although some lineages such as HNSC and PAAD show a favorable association.

UVM, CESC, and HNSC are the cancer types where ST20-MTHFS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.253	0.774	<.001	117	view →
CESC	OS	Tertile	III,IV	0.106	0.505	.003	76	view →
HNSC	OS	Tertile	II,III,IV	0.798	0.686	.004	60	view →
LUAD	OS	Median	All	0.297	0.415	.002	52	view →
LGG	OS	Median	All	0.360	0.520	<.001	50	view →
PAAD	OS	Tertile	All	0.578	0.369	.006	36	view →
KIRC	DFS	Quartile	II,III,IV	0.643	0.294	.002	26	view →
BRCA	DFS	Tertile	IV	0.398	0.945	.004	16	view →
STAD	DFS	Quartile	II,III,IV	0.572	0.782	.016	15	view →
COAD	OS	Median	All	0.814	0.919	.004	14	view →
UCS	OS	Quartile	II,III,IV	0.197	0.614	.009	12	view →
ACC	DFS	Tertile	IV	0.597	0.113	.006	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ST20-MTHFS–UVM (DFS)

Open the UVM breakdown →