ST20-MTHFS

Across TCGA pan-cancer cohorts, ST20-MTHFS RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ST20-MTHFS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ST20-MTHFS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ST20-MTHFS is over-expressed in tumor.

HNSC, KIRC, and CHOL are the cancer types where ST20-MTHFS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST20-MTHFS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.198	<.001	11	view →
KIRC	All	All	+0.099	<.001	9	view →
CHOL	All	All	+0.297	.004	4	view →
BRCA	Female	All	+0.130	<.001	4	view →
STAD	Female	All	+0.137	.015	3	view →
LIHC	All	All	+0.150	.004	2	view →
LUAD	All	All	+0.132	.005	2	view →
LUSC	All	All	+0.109	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ST20-MTHFS–HNSC

Open the HNSC breakdown →