ST20-MTHFS

Across TCGA patient cohorts, ST20-MTHFS mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST20-MTHFS-associated genes across cancer lineages are p62 Lck ligand, PDCD4, and PKC-a. Each is linked with ST20-MTHFS in more than 1 cancer types. Because this analysis shows association rather than direction, both ST20-MTHFS-to-partner and partner-to-ST20-MTHFS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ST20-MTHFS-low versus ST20-MTHFS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST20-MTHFS→partner) and Y-score (partner→ST20-MTHFS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.510	+3.000	.006	.037	1	1
UCEC	PDCD4 →	-0.711	-3.000	.008	.037	1	1
UCEC	PKC-a →	+0.503	+3.000	.031	.037	1	1
UCEC	ASNS →	+0.687	+3.000	<.001	.037	1	1
UCEC	Cyclin-B1 →	+0.648	+3.000	.045	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by ST20-MTHFS expression — UCEC

Explore this box plot interactively →