ST18

Across TCGA cell cohorts, ST18 mutation is significantly associated with the RNA expression of many other genes, with 574 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ST18-associated genes across cancer lineages are ZBTB8A, CT45A7, and SI. Each is linked with ST18 in more than 2 cancer types. Because this analysis shows association rather than direction, both ST18-to-partner and partner-to-ST18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB8A grouped by ST18-low versus ST18-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST18→partner) and Y-score (partner→ST18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZBTB8A →	+0.614	+3.169	.001	.006	3	3
BLOOD_Myeloma	CT45A7 →	+0.191	+4.285	.001	.003	3	2
PANCREAS	SI →	+0.107	+3.067	<.001	.004	3	2
OESOPHAGUS	SPZ1 →	+0.530	+4.906	<.001	.006	3	2
LARGE_INTESTINE	ERI3 →	+0.376	+2.628	.006	.002	3	2
LARGE_INTESTINE	NTPCR →	+0.548	+3.169	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 574 associations by consensus.

ZBTB8A by ST18 expression — LARGE_INTESTINE

Explore this box plot interactively →