ST18

Across TCGA pan-cancer cohorts, ST18 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ST18 data layer compared with 12 for mutation status.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher ST18 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ST18 expression acts as an unfavorable survival marker, although some lineages such as PAAD and DLBC show a favorable association.

PAAD, DLBC, and HNSC are the cancer types where ST18 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	DFS	Median	All	0.379	0.197	<.001	44	view →
DLBC	DFS	Median	II,III,IV	1.000	0.189	.003	32	view →
HNSC	DFS	Tertile	IV	0.486	0.296	.004	28	view →
SARC	DFS	Median	All	0.514	0.693	<.001	26	view →
READ	DFS	Quartile	All	0.539	0.953	.001	22	view →
LAML	DFS	Quartile	All	0.580	0.369	.016	20	view →
SKCM	OS	Quartile	III,IV	0.609	0.162	<.001	19	view →
ESCA	OS	Median	All	0.577	1.000	.005	15	view →
ACC	OS	Tertile	III,IV	0.306	0.807	.001	15	view →
LUAD	OS	Quartile	III,IV	0.681	0.303	.016	11	view →
LIHC	DFS	Tertile	All	0.277	0.509	.007	10	view →
UVM	OS	Tertile	III,IV	0.286	0.836	.019	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ST18–PAAD (DFS)

Open the PAAD breakdown →