ST18

Across TCGA pan-cancer cohorts, ST18 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ST18’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ST18 RNA is repressed in tumor relative to normal tissue. In most cancer types ST18 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, KIRP, and BRCA are the cancer types where ST18 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST18 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	II,III,IV	−0.087	<.001	7	view →
KIRP	All	All	−0.075	.004	7	view →
BRCA	Female	All	+0.081	<.001	4	view →
LUSC	All	All	+0.257	.008	3	view →
ESCA	All	All	−0.311	.011	1	view →
LUAD	All	All	+0.183	.021	1	view →
COAD	Female	III,IV	−0.167	.046	1	view →
READ	Female	All	−0.128	.030	1	view →
CHOL	All	All	+0.036	.027	1	view →
THCA	All	All	−0.022	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ST18–KICH

Open the KICH breakdown →