ST14

Across TCGA patient cohorts, ST14 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ST14-associated genes across cancer lineages are ATM, mTOR_pS2448, and p90 RSK. Each is linked with ST14 in more than 3 cancer types. Because this analysis shows association rather than direction, both ST14-to-partner and partner-to-ST14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ST14-low versus ST14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST14→partner) and Y-score (partner→ST14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.344	-1.893	.011	.014	3	4
UCEC	mTOR_pS2448 →	-0.107	-1.420	.016	.022	3	3
UCEC	p90 RSK →	+0.145	+1.197	.011	.014	3	3
UCEC	Rad50 →	-0.227	-1.807	.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.603	+1.382	<.001	.021	3	3
UCEC	Lck →	+0.173	+1.678	.003	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by ST14 expression — UCEC

Explore this box plot interactively →