ST14

Across TCGA pan-cancer cohorts, ST14 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ST14 data layer compared with 8 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ST14 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ST14 expression acts as an unfavorable survival marker, although some lineages such as KIRP and THCA show a favorable association.

KIRP, BRCA, and UVM are the cancer types where ST14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.815	0.575	<.001	102	view →
BRCA	OS	Tertile	II,III,IV	0.864	0.956	<.001	67	view →
UVM	DFS	Median	All	0.435	0.725	.001	55	view →
ACC	OS	Tertile	II,III,IV	0.629	0.931	.001	49	view →
LGG	OS	Median	All	0.341	0.581	<.001	45	view →
THCA	OS	Quartile	All	1.000	0.890	.004	39	view →
LAML	DFS	Tertile	All	0.472	0.813	.002	30	view →
PAAD	DFS	Tertile	All	0.412	0.664	.011	21	view →
COAD	OS	Median	IV	0.749	0.348	<.001	20	view →
BLCA	OS	Tertile	All	0.444	0.729	.017	19	view →
ESCA	OS	Median	All	0.617	1.000	.009	15	view →
LUAD	DFS	Median	IV	0.741	0.260	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ST14–KIRP (OS)

Open the KIRP breakdown →