ST14

Across TCGA pan-cancer cohorts, ST14 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ST14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ST14 RNA is repressed in tumor relative to normal tissue. In most cancer types ST14 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

KIRC, THCA, and LUAD are the cancer types where ST14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ST14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−2.244	<.001	11	view →
THCA	Male	III,IV	+0.804	<.001	10	view →
LUAD	Male	III,IV	+1.698	<.001	9	view →
BLCA	All	III,IV	+2.555	.003	8	view →
LUSC	Male	II,III,IV	+1.456	<.001	7	view →
UCEC	All	All	+2.982	<.001	6	view →
STAD	All	II,III,IV	+2.149	<.001	6	view →
BRCA	All	All	+1.002	<.001	6	view →
CHOL	Male	All	+3.859	<.001	5	view →
LIHC	All	All	+0.671	.012	4	view →
KICH	Female	All	+0.950	.003	2	view →
PRAD	All	All	+0.736	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ST14–KIRC

Open the KIRC breakdown →