ST14

Across TCGA cell cohorts, ST14 mutation is significantly associated with the RNA expression of many other genes, with 420 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ST14-associated genes across cancer lineages are NAA38, MTFR1, and SCYGR2. Each is linked with ST14 in more than 1 cancer types. Because this analysis shows association rather than direction, both ST14-to-partner and partner-to-ST14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAA38 grouped by ST14-low versus ST14-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ST14→partner) and Y-score (partner→ST14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NAA38 →	+1.028	+3.628	<.001	<.001	3	2
LARGE_INTESTINE	MTFR1 →	+0.628	+3.321	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	SCYGR2 →	+0.125	+4.357	<.001	.006	3	2
LUNG_NSCLC_LUAD	GYPB →	+0.069	+2.959	<.001	.004	3	2
PANCREAS	OR4S2 →	+0.013	+4.029	<.001	.007	3	1
PANCREAS	ADH1B →	+0.625	+3.491	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 420 associations by consensus.

NAA38 by ST14 expression — LARGE_INTESTINE

Explore this box plot interactively →