SSX5

Across TCGA patient cohorts, SSX5 mutation is significantly associated with the RNA expression of many other genes, with 4,216 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSX5-associated genes across cancer lineages are OR5L2, MIR4695, and H2AC14. Each is linked with SSX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSX5-to-partner and partner-to-SSX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5L2 grouped by SSX5-low versus SSX5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSX5→partner) and Y-score (partner→SSX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR5L2 →	+0.034	+7.930	<.001	.008	3	2
LUAD	MIR4695 →	+0.348	+7.930	<.001	.008	3	2
UCEC	H2AC14 →	+1.005	+3.180	<.001	<.001	3	2
COAD	C1QBPP1 →	+0.112	+5.283	<.001	.006	3	2
UCEC	KXD1 →	+0.436	+2.233	<.001	<.001	3	2
UCEC	ANAPC15 →	+0.464	+1.874	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,216 associations by consensus.

OR5L2 by SSX5 expression — LUAD

Explore this box plot interactively →