SSX5

Across TCGA pan-cancer cohorts, SSX5 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated SSX5 data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher SSX5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SSX5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BRCA show a favorable association.

UVM, KICH, and ACC are the cancer types where SSX5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.388	0.804	<.001	134	view →
KICH	OS	Tertile	All	0.082	0.877	<.001	54	view →
ACC	OS	Median	All	0.772	0.931	.002	42	view →
KIRC	DFS	Quartile	II,III,IV	0.515	0.699	.010	41	view →
DLBC	OS	Tertile	IV	0.342	0.930	.045	18	view →
LUAD	DFS	Tertile	IV	0.382	0.739	.045	18	view →
LAML	DFS	Tertile	All	0.322	0.608	.026	18	view →
SKCM	DFS	Median	II,III,IV	0.328	0.199	.003	14	view →
LIHC	OS	Quartile	All	0.656	0.813	.008	9	view →
BRCA	DFS	Tertile	III,IV	0.960	0.857	.038	6	view →
BLCA	DFS	Tertile	III,IV	0.497	0.259	.035	3	view →
LGG	OS	Tertile	All	0.766	0.896	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

SSX5–UVM (DFS)

Open the UVM breakdown →