SSX5

Across TCGA pan-cancer cohorts, SSX5 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of SSX5’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SSX5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SSX5 is over-expressed in tumor, although a few such as BRCA and LUSC show the opposite, repressed pattern.

THCA, LIHC, and BRCA are the cancer types where SSX5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SSX5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	+0.274	.005	2	view →
LIHC	All	All	+0.255	.021	2	view →
BRCA	All	IV	−0.065	.005	2	view →
KIRP	All	II,III,IV	+0.043	.046	1	view →
LUSC	Male	All	−0.015	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

SSX5–THCA

Open the THCA breakdown →