SSX5

Across TCGA patient cohorts, SSX5 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSX5-associated genes across cancer lineages are p70-S6K, ASNS, and 14-3-3_beta. Each is linked with SSX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSX5-to-partner and partner-to-SSX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K grouped by SSX5-low versus SSX5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSX5→partner) and Y-score (partner→SSX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K →	+0.162	+2.341	.025	.019	3	2
UCEC	ASNS →	+0.570	+2.169	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.121	-1.752	.001	.014	3	1
UCEC	EGFR_pY1068 →	-0.242	-3.459	.010	.005	3	1
UCEC	eIF4G →	+0.310	+2.321	.007	.033	3	1
UCEC	A-Raf_pS299 →	-0.125	-2.584	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

p70-S6K by SSX5 expression — UCEC

Explore this box plot interactively →