SSX5

Across TCGA cell cohorts, SSX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 530 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SSX5-associated GO terms across cancer lineages are Negative regulation of cytoplasmic pattern recognition receptor signaling pathway, Positive regulation of inflammatory response to wounding, and ATP metabolic process. Each is linked with SSX5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SSX5-to-partner and partner-to-SSX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway grouped by SSX5-low versus SSX5-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SSX5→partner) and Y-score (partner→SSX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.052	+0.219	.003	.001	3	4
BLOOD_Leukemia	Positive regulation of inflammatory response to wounding →	+0.130	+0.154	.005	.003	3	4
OVARY	ATP metabolic process →	+0.055	+0.174	.008	.005	3	3
BLOOD_Myeloma	Positive regulation of innate immune response →	+0.031	+0.027	.005	.008	3	3
BLOOD_Leukemia	Negative regulation of ubiquitin-protein transferase activity →	+0.071	+0.146	.004	.003	3	3
BLOOD_Leukemia	Plasma membrane invagination →	-0.090	-0.172	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 530 associations by consensus.

Negative regulation of cytoplasmic pattern recognition receptor signaling pathway by SSX5 expression — OVARY

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