SSX5

Across TCGA cell cohorts, SSX5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SSX5-associated genes across cancer lineages are GHRHR, MAGEB4, and STRA8. Each is linked with SSX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SSX5-to-partner and partner-to-SSX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHRHR grouped by SSX5-low versus SSX5-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSX5→partner) and Y-score (partner→SSX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GHRHR →	+0.069	+5.087	<.001	.004	3	1
LARGE_INTESTINE	MAGEB4 →	+0.029	+5.415	<.001	.004	3	1
LARGE_INTESTINE	STRA8 →	+0.215	+5.415	<.001	.004	3	1
LARGE_INTESTINE	ZNF804B →	+0.022	+5.415	<.001	.004	3	1
LARGE_INTESTINE	DAZ2 →	+0.336	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GHRHR by SSX5 expression — URINARY_TRACT

Explore this box plot interactively →