SSB

Across TCGA patient cohorts, SSB mutation is significantly associated with the RNA expression of many other genes, with 897 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SSB-associated genes across cancer lineages are LINC01607, TBC1D8-AS1, and CYFIP1. Each is linked with SSB in more than 1 cancer types. Because this analysis shows association rather than direction, both SSB-to-partner and partner-to-SSB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01607 grouped by SSB-low versus SSB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SSB→partner) and Y-score (partner→SSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01607 →	-0.742	-2.885	<.001	.001	3	1
UCEC	TBC1D8-AS1 →	-0.329	-2.598	.004	<.001	3	1
UCEC	CYFIP1 →	+0.512	+2.724	.002	.003	3	1
UCEC	MIR6842 →	+0.197	+3.059	<.001	.005	3	1
UCEC	TAF9 →	+0.424	+2.169	.005	.003	3	1
UCEC	MIR7702 →	+0.163	+3.738	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 897 associations by consensus.

LINC01607 by SSB expression — UCEC

Explore this box plot interactively →