SSB

Across TCGA pan-cancer cohorts, SSB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SSB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SSB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SSB is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LIHC, and KICH are the cancer types where SSB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SSB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.250	<.001	12	view →
LIHC	Male	II,III,IV	+1.324	<.001	9	view →
KICH	Female	II,III,IV	−1.764	<.001	8	view →
STAD	All	II,III,IV	+0.968	<.001	8	view →
COAD	Male	All	+0.892	<.001	8	view →
BLCA	All	All	+0.596	<.001	8	view →
LUSC	Female	All	+0.710	<.001	6	view →
LUAD	Male	II,III,IV	+0.572	<.001	6	view →
CHOL	Male	All	+2.219	<.001	5	view →
READ	All	III,IV	+1.274	.006	3	view →
KIRP	All	II,III,IV	+0.396	.041	3	view →
ESCA	All	All	+1.149	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SSB–HNSC

Open the HNSC breakdown →