SSB

Across TCGA pan-cancer cohorts, SSB RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated SSB data layer compared with 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SSB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SSB expression acts as an unfavorable survival marker, although some lineages such as KIRC and THCA show a favorable association.

KIRP, ACC, and LIHC are the cancer types where SSB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.504	0.674	<.001	128	view →
ACC	DFS	Median	All	0.251	0.635	<.001	106	view →
LIHC	OS	Median	All	0.605	0.762	<.001	89	view →
HNSC	DFS	Median	All	0.533	0.671	<.001	84	view →
LUAD	DFS	Median	All	0.726	0.850	<.001	40	view →
LGG	OS	Median	All	0.754	0.867	<.001	38	view →
KICH	DFS	Quartile	II,III,IV	0.514	1.000	.007	30	view →
UVM	DFS	Quartile	III,IV	0.183	0.814	.001	30	view →
MESO	OS	Median	All	0.446	0.638	.005	28	view →
UCEC	DFS	Quartile	All	0.642	0.857	.002	26	view →
PAAD	DFS	Quartile	All	0.182	0.441	.001	23	view →
KIRC	DFS	Median	III,IV	0.731	0.534	.015	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

SSB–KIRP (DFS)

Open the KIRP breakdown →