SS18

Across TCGA cell cohorts, SS18 mutation is significantly associated with the mutation status of many other genes, with 1,972 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SS18-associated genes across cancer lineages are CDH7, NOA1, and PPP1R12A. Each is linked with SS18 in more than 2 cancer types. Because this analysis shows association rather than direction, both SS18-to-partner and partner-to-SS18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDH7 grouped by SS18-low versus SS18-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SS18→partner) and Y-score (partner→SS18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CDH7 →	+3.857	+4.807	.002	.002	1	3
BREAST	NOA1 →	+4.857	+4.297	.009	.009	1	3
BLOOD_Leukemia	PPP1R12A →	+4.560	+4.309	.007	.007	1	3
BLOOD_Lymphoma	ASXL2 →	+5.014	+5.584	.003	.003	1	3
BLOOD_Lymphoma	TBCK →	+4.429	+5.247	.005	.005	1	3
BLOOD_Lymphoma	LARP1 →	+4.014	+4.969	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,972 associations by consensus.

CDH7 by SS18 expression — BREAST

Explore this box plot interactively →