SRRT

Across TCGA patient cohorts, SRRT mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRT-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and ATM. Each is linked with SRRT in more than 1 cancer types. Because this analysis shows association rather than direction, both SRRT-to-partner and partner-to-SRRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SRRT-low versus SRRT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRT→partner) and Y-score (partner→SRRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.242	-1.584	<.001	.001	3	2
UCEC	PDCD4 →	-0.526	-2.247	<.001	.001	3	2
UCEC	ATM →	-0.568	-1.784	<.001	<.001	3	2
UCEC	Caspase-8 →	-0.203	-2.558	.004	<.001	3	2
UCEC	C-Raf →	+0.117	+1.415	.004	.008	3	2
UCEC	14-3-3_beta →	-0.068	-1.738	.016	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

EGFR_pY1068 by SRRT expression — UCEC

Explore this box plot interactively →