SRRT

Across TCGA cell cohorts, SRRT mutation is significantly associated with the RNA expression of many other genes, with 1,159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRRT-associated genes across cancer lineages are ZNF346, F9, and GNG8. Each is linked with SRRT in more than 1 cancer types. Because this analysis shows association rather than direction, both SRRT-to-partner and partner-to-SRRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF346 grouped by SRRT-low versus SRRT-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRT→partner) and Y-score (partner→SRRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF346 →	+0.573	+3.459	.001	<.001	3	2
CNS	F9 →	+0.016	+4.321	.002	.009	3	1
CNS	GNG8 →	+1.387	+4.643	<.001	.003	3	1
LUNG_NSCLC_LUAD	PNMA6F →	+0.012	+4.887	<.001	.009	3	1
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	1
OVARY	C12orf40 →	+0.008	+3.444	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,159 associations by consensus.

ZNF346 by SRRT expression — LARGE_INTESTINE

Explore this box plot interactively →