SRRM4

Across TCGA patient cohorts, SRRM4 mutation is significantly associated with the RNA expression of many other genes, with 3,522 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRRM4-associated genes across cancer lineages are SNORD82, CDV3P1, and CTDNEP1. Each is linked with SRRM4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SRRM4-to-partner and partner-to-SRRM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD82 grouped by SRRM4-low versus SRRM4-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRRM4→partner) and Y-score (partner→SRRM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	SNORD82 →	+0.628	+5.166	<.001	.001	3	4
BRCA	CDV3P1 →	+0.065	+3.273	.002	.009	3	3
UCEC	CTDNEP1 →	+0.287	+1.852	<.001	<.001	3	3
UCEC	MAP2K3 →	+0.521	+1.830	<.001	<.001	3	3
COAD	RELT →	+0.415	+2.584	.001	.001	3	3
SKCM	EVA1C →	+0.838	+3.623	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,522 associations by consensus.

SNORD82 by SRRM4 expression — PRAD

Explore this box plot interactively →