SRPX

Across TCGA patient cohorts, SRPX mutation is significantly associated with the RNA expression of many other genes, with 778 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPX-associated genes across cancer lineages are RNU4-84P, KATNBL1P4, and RNU6-492P. Each is linked with SRPX in more than 2 cancer types. Because this analysis shows association rather than direction, both SRPX-to-partner and partner-to-SRPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-84P grouped by SRPX-low versus SRPX-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPX→partner) and Y-score (partner→SRPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU4-84P →	+0.116	+5.005	.001	.002	3	3
COAD	KATNBL1P4 →	+0.065	+5.409	.003	.001	3	2
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
LUSC	RPL11P4 →	+0.146	+4.204	.007	.001	3	2
LUSC	RN7SKP250 →	+0.096	+5.005	<.001	.002	3	2
LUSC	RNU6-601P →	+0.175	+5.005	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 778 associations by consensus.

RNU4-84P by SRPX expression — LUSC

Explore this box plot interactively →