SRPX

Across TCGA pan-cancer cohorts, SRPX RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of SRPX’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SRPX RNA is repressed in tumor relative to normal tissue. In most cancer types SRPX is over-expressed in tumor, although a few such as COAD and BLCA show the opposite, repressed pattern.

COAD, BLCA, and LUAD are the cancer types where SRPX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRPX RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−2.285	<.001	12	view →
BLCA	Male	IV	−3.720	<.001	11	view →
LUAD	Female	III,IV	−2.100	<.001	11	view →
THCA	Male	II,III,IV	−2.050	<.001	9	view →
UCEC	All	All	−3.613	<.001	8	view →
LIHC	Male	All	−2.361	<.001	8	view →
STAD	All	All	−1.498	<.001	8	view →
BRCA	All	II,III,IV	−2.464	<.001	6	view →
LUSC	Female	II,III,IV	−2.192	<.001	6	view →
READ	Female	All	−3.892	<.001	3	view →
KICH	All	All	−1.003	.016	3	view →
CHOL	All	II,III,IV	−2.015	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

SRPX–COAD

Open the COAD breakdown →