SRPX

Across TCGA pan-cancer cohorts, SRPX RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SRPX data layer compared with 8 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher SRPX RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SRPX expression acts as an unfavorable survival marker, although some lineages such as CHOL and PRAD show a favorable association.

KIRP, HNSC, and UCEC are the cancer types where SRPX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.528	0.800	<.001	139	view →
HNSC	DFS	Tertile	All	0.631	0.771	<.001	91	view →
UCEC	OS	Median	All	0.597	0.743	<.001	58	view →
BLCA	OS	Tertile	All	0.318	0.546	<.001	57	view →
UVM	DFS	Tertile	All	0.415	0.883	<.001	49	view →
MESO	OS	Quartile	III,IV	0.413	0.718	.003	45	view →
ACC	DFS	Median	IV	0.165	0.526	.009	29	view →
COAD	DFS	Tertile	II,III,IV	0.276	0.744	<.001	25	view →
SCLC	OS	Tertile	IV	0.164	0.647	.017	24	view →
CESC	OS	Quartile	All	0.456	0.773	.008	24	view →
CHOL	DFS	Tertile	All	0.766	0.125	<.001	18	view →
PRAD	DFS	Tertile	All	0.876	0.749	.013	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SRPX–KIRP (OS)

Open the KIRP breakdown →