SRPX

Across TCGA patient cohorts, SRPX mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRPX-associated genes across cancer lineages are Rad50, 4E-BP1, and EGFR_pY1068. Each is linked with SRPX in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPX-to-partner and partner-to-SRPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by SRPX-low versus SRPX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPX→partner) and Y-score (partner→SRPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.201	-1.502	.023	.030	3	2
UCEC	4E-BP1 →	+0.257	+3.169	.009	.018	3	2
UCEC	EGFR_pY1068 →	-0.195	-1.874	.034	.049	3	1
UCEC	eIF4E →	+0.189	+3.472	.014	.002	3	1
UCEC	Ku80 →	+0.275	+1.710	.001	.025	3	1
UCEC	MEK1 →	+0.470	+2.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Rad50 by SRPX expression — UCEC

Explore this box plot interactively →