SRPX

Across TCGA cell cohorts, SRPX mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SRPX-associated genes across cancer lineages are PRSS38, TRIM60, and LUZP4. Each is linked with SRPX in more than 1 cancer types. Because this analysis shows association rather than direction, both SRPX-to-partner and partner-to-SRPX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS38 grouped by SRPX-low versus SRPX-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPX→partner) and Y-score (partner→SRPX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRSS38 →	+0.205	+5.201	<.001	.006	3	2
LUNG_NSCLC_LUAD	TRIM60 →	+0.036	+5.228	<.001	.005	3	1
BLOOD_Lymphoma	LUZP4 →	+0.085	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	ASB11 →	+0.063	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	OR4N4 →	+0.071	+4.191	<.001	.007	3	1
BLOOD_Lymphoma	S100A7A →	+0.026	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

PRSS38 by SRPX expression — BLOOD_Leukemia

Explore this box plot interactively →