SRPRB

Across TCGA patient cohorts, SRPRB protein abundance is significantly associated with the RNA expression of many other genes, with 10,174 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SRPRB-associated genes across cancer lineages are CNRIP1, TBCK, and TNXB. Each is linked with SRPRB in more than 4 cancer types. Because this analysis shows association rather than direction, both SRPRB-to-partner and partner-to-SRPRB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SRPRB versus CNRIP1 in CCRCC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRPRB→partner) and Y-score (partner→SRPRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CNRIP1 →	-0.765	-0.433	<.001	<.001	3	5
BRCA	TBCK →	-0.449	-0.505	.003	<.001	3	5
UCEC	TNXB →	-1.173	-0.427	<.001	<.001	3	5
CCRCC	PLAC9 →	-0.802	-0.338	<.001	<.001	3	5
CCRCC	KLHDC1 →	-0.696	-0.496	<.001	<.001	3	5
CCRCC	GPRASP1 →	-0.698	-0.465	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,174 associations by consensus.

SRPRB vs CNRIP1 — CCRCC

Explore this scatter interactively →