SRPRB

Across TCGA pan-cancer cohorts, SRPRB RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of SRPRB’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SRPRB RNA is repressed in tumor relative to normal tissue. In most cancer types SRPRB is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and COAD are the cancer types where SRPRB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SRPRB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	IV	−1.412	<.001	9	view →
LIHC	Male	II,III,IV	+1.274	<.001	9	view →
COAD	Female	II,III,IV	+1.111	<.001	9	view →
LUAD	Female	II,III,IV	+1.085	<.001	9	view →
KIRP	All	II,III,IV	+0.649	<.001	9	view →
LUSC	Female	All	+1.220	<.001	8	view →
BLCA	Male	III,IV	+1.141	<.001	8	view →
HNSC	Male	IV	+0.970	<.001	8	view →
BRCA	All	III,IV	+0.853	<.001	8	view →
STAD	All	All	+0.806	<.001	7	view →
UCEC	All	III,IV	+1.072	<.001	6	view →
CHOL	Male	All	+1.390	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

SRPRB–THCA

Open the THCA breakdown →