G protein-coupled receptor associated sorting protein 1Genealiases: GASP · GASP-1 · GASP1
Q-omics provides the consensus-scored GPRASP1 profile across patient tissues and cancer cell-line models. GPRASP1 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, GPRASP1 is differentially expressed in 17, with the highest sampling consensus in KICH. Additionally, GPRASP1 RNA expression shows 24,033 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight HNSC, KICH, and GBM as cancer lineages where GPRASP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for GPRASP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes GPRASP1 survival associations across molecular data types. GPRASP1 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (10) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible GPRASP1 RNA expression–survival associations across cancer types. High GPRASP1 expression shows unfavorable associations in LGG, but favorable associations in HNSC, LUAD, PAAD, BRCA and KIRC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for GPRASP1 RNA expression.
This table summarizes GPRASP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 17, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRP for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for GPRASP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. GPRASP1 shows lower tumor expression in KICH, BLCA, KIRP, COAD, LUAD and KIRC. The KICH box plot shows higher GPRASP1 RNA expression in normal versus tumor tissue (log2 FC = −2.592, t-test p < 0.001).
This table shows molecular features associated with GPRASP1 in patient tissues and cancer cell lines. In patient samples, GPRASP1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, GPRASP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in LIVER and BLOOD_Leukemia.
