SRP72

Across TCGA patient cohorts, SRP72 mutation is significantly associated with the RNA expression of many other genes, with 1,734 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SRP72-associated genes across cancer lineages are PPIHP2, SALL4P6, and PIEZO1P2. Each is linked with SRP72 in more than 1 cancer types. Because this analysis shows association rather than direction, both SRP72-to-partner and partner-to-SRP72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIHP2 grouped by SRP72-low versus SRP72-high in ACC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP72→partner) and Y-score (partner→SRP72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	PPIHP2 →	+0.120	+4.887	<.001	.009	3	2
COAD	SALL4P6 →	+0.239	+3.789	<.001	.004	3	2
ACC	PIEZO1P2 →	+0.037	+4.887	<.001	.009	3	2
CESC	SNORA36A →	+0.274	+3.653	<.001	.009	3	2
UCEC	NOL12 →	+0.276	+1.939	.003	.008	3	2
UCEC	RNA5SP414 →	+0.527	+1.863	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,734 associations by consensus.

PPIHP2 by SRP72 expression — ACC

Explore this box plot interactively →