SRP72

Across TCGA pan-cancer cohorts, SRP72 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated SRP72 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SRP72 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SRP72 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

CESC, LIHC, and KIRP are the cancer types where SRP72 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Quartile	III,IV	0.302	0.820	.002	74	view →
LIHC	OS	Tertile	All	0.564	0.799	<.001	73	view →
KIRP	OS	Median	All	0.894	0.967	.001	66	view →
KIRC	DFS	Median	All	0.699	0.555	<.001	62	view →
UCS	DFS	Median	IV	0.952	0.367	.001	58	view →
READ	OS	Median	II,III,IV	0.927	0.461	.002	48	view →
PAAD	OS	Median	All	0.400	0.653	.002	38	view →
THCA	OS	Median	All	0.963	1.000	.014	37	view →
ACC	DFS	Quartile	All	0.267	0.713	.003	37	view →
KICH	DFS	Tertile	All	0.545	0.921	.004	35	view →
UVM	DFS	Quartile	All	0.281	0.745	.009	31	view →
LGG	OS	Median	All	0.854	0.937	<.001	27	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

SRP72–CESC (OS)

Open the CESC breakdown →