SRP72

Across TCGA cell cohorts, SRP72 mutation is significantly associated with the mutation status of many other genes, with 3,607 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SRP72-associated genes across cancer lineages are RNF128, CARD11, and ANO2. Each is linked with SRP72 in more than 4 cancer types. Because this analysis shows association rather than direction, both SRP72-to-partner and partner-to-SRP72 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF128 grouped by SRP72-low versus SRP72-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SRP72→partner) and Y-score (partner→SRP72) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RNF128 →	+4.807	+4.807	.008	.008	1	5
LARGE_INTESTINE	CARD11 →	+1.884	+3.064	.003	.003	1	4
OVARY	ANO2 →	+3.240	+4.467	.004	.004	1	4
KIDNEY	LRP5 →	+3.139	+4.237	.006	.006	1	3
LARGE_INTESTINE	DES →	+3.584	+3.007	.008	.008	1	3
LARGE_INTESTINE	POLE →	+2.125	+3.278	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,607 associations by consensus.

RNF128 by SRP72 expression — STOMACH

Explore this box plot interactively →